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KMID : 1094020140310030253
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Journal of Veterinary Clinics
2014 Volume.31 No. 3 p.253 ~ p.257
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Clinical Application of Autologous Adipose Tissue Derived Mesenchymal Stem Cells in Five Dogs with Stifle Joint Osteoarthrosis
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Yoon Hun-young
Jeong Soon-Wuk
Kang Dong-Jun
Lee Soo-Han
Chung Byung-Hyun
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Abstract
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Five dogs presented with a history of pelvic limb lameness. On physical examination of the stifle joints,five dogs had pain, lameness, patellar luxation, or ligamentous instability. Craniocaudal and mediolateral radiographicprojections revealed osteophytes or subchondral cystic lesions on the stifle joints. Based on a previously describedOsteoarthrosis (OA) scoring technique, five dogs showed high OA scores. Combination of surgery and implantationof autologous adipose tissue derived mesenchymal stem cells (aAT-MSCs) or percutaneous injection of aAT-MSCswas determined with informed consent. 1 × 106 aAT-MSCs suspended in PBS was injected in the stifle joints. Thefollow-ups were completed 12 months after surgery. The follow-up information was based on physical examinationby veterinarians. The lameness, pain on manipulation, and OA scores improved six or 12 months after implantationof aAT-MSCs. There was a radiographic evidence of decreased osteophytes and subchondral cystic lesions. These resultssuggest that implantation of aAT-MSCs can be considered an option for management of cases of OA in the stifle joints.
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KEYWORD
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autologous adipose tissue-derived stem cells, stifle joint, osteoarthrosis, dog
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